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Best Acne Spot Treatments

Sephora customers often prefer the following products when searching for Best Acne Spot Treatments.

Acne can be a frustrating and confidence-denting skin concern that many of us have experienced at some point. When those pesky pimples pop up, it's important to have effective spot treatments on hand to help combat them. Whether you're dealing with occasional breakouts or persistent blemishes, these acne spot treatments are here to save the day. These targeted solutions are designed to help reduce the appearance of acne, minimize redness, and promote clearer-looking skin.

OriginsSuper Spot Remover™ Acne Treatment Gel with Salicylic Acid

ITEM: 1375690

Size: 0.3 oz/ 10 mL

1.8K Reviews

$30.00

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I am glad I finally decided to buy this acne spot treatment . It smells bad but the scent isn’t overwhelming. ...Very effective acne treatment, helps the skin to regenerate and eradicate the acnes more quickly....Very effective acne treatment

What it is: An acne treatment gel with 1.5% Salicylic Acid for on-the-spot, targeted treatment––wherever you go.


Skin Type: Normal, Dry, and Oily


Skincare Concerns: Acne and Blemishes, Redness, and Oiliness


Formulation: Gel


Highlighted Ingredients:

- Saw Palmetto: Helps control oil, reduce shine, and prevent breakouts.


What Else You Need to Know: This blemish-fighting formula with saw palmetto and 1.5 percent salicylic acid helps eliminate excess oil that can lead to break outs.

$151.00

Unlike some other retinoid treatments, the Equilibrium Resurfacing Retinoid Treatment does not cause irritation or redness, making it suitable for most sensitive skin types.I have noticed a significant improvement in the overall texture and tone of my skin. ...Love using this treatment and I’m truly amazed by the results. This retinol treatment helps to reduce dark spots and fine line and wrinkles.

What it is: A lightweight resurfacing treatment that boosts clarity and helps visibly even skin texture and tone for more balanced skin with a healthy glow.

Highlighted Ingredients:
- Retinoid, Hexylresorcinol, and Niacinamide: A clinically backed blend that visibly reduces fine lines and wrinkles and diminishes the appearance of dark spots and hyperpigmentation while being gentle to skin.

Ingredient Callouts: Free of parabens and mineral oil. It is also cruelty-free.

What Else You Need to Know: This fast-absorbing treatment is formulated with a blend of a retinoid, hexylresorcinol, and niacinamide to visibly reduce fine lines and wrinkles and diminish the appearance of dark spots and hyperpigmentation. The formula is ef

$13.40

Must have spot treatment...The ordinary sulfur acne powder to cream treatment perfect for spot treatments! ...As someone who struggles with cystic acne, this spot treatment has been great to not have to put heavy creams and treatments all over my face.

What it is: A targeted breakout solution that starts to work upon application, visibly reducing blemish size and redness in under one hour.

Skin Type: Oily

Skincare Concerns: Acne and Blemishes, Oiliness, and Redness

Highlighted Ingredients:
- Sulfur 10%
- L-Carnitine 5%
- Niacinamide 4%

Ingredient Callouts: Free of formaldehydes, formaldehyde-releasing agents, mineral oil, coal tar, and hydroquinone.

What Else You Need to Know: This unique powder-to-cream formula allows for adjustable dispensing and is easy to use on the go. When pressure is applied during application, the powder transforms into a light emulsion that discreetly blends into your skin.

$45.00

The perfect moisturizing treatment!...You get quite a lot of product compared to other body treatments, Definitely recommend....This body treatment really has a beautiful texture and sinks into my skin leaving it very soft.

What it is: A leave-on body exfoliant, made with two percent BHA, that gently sheds dulling buildup to smooth rough, bumpy textures and reveal soft, glowing skin all over.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns:
Redness, Dullness, and Uneven Texture

Formulation: Cream

Highlighted Ingredients:
- 2% Salicylic Acid (BHA): Exfoliates to diminish buildup and smooth the look of bumpy textures.
- Vitamin E: Visibly softens while supporting environmental protection.
- Chamomile and Green Tea: Provide light, lasting hydration while soothing irritation.

Ingredient Callouts: Free of parabens, formaldehydes, formaldehyde-releasing agents, phthalates, retinyl

$97.00

Over time, the treatment helped reduce the appearance of fine lines, minimized my pores, and brightened my overall complexion. ...[I received this product in exchange for my honest review] I have oily, acne‑prone skin and was nervous about using a retinoid, but this Paula’s Choice Clinical Pro Retinaldehyde Dual‑Retinoid Treatment has blown me away.

What it is: A high-potency retinoid formula that delivers dermatologist-level results for clear, luminous skin with minimal irritation—no prescription needed.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Fine Lines and Wrinkles, Acne and Blemishes, and Loss of Firmness and Elasticity

Formulation: Liquid

Highlighted Ingredients:
- Retinaldehyde: Calcium-encapsulated for advanced results with minimized irritation.
- Pomegranate Peel Extract: Supports healthy collagen levels and soothes skin.
- Albatrellus Confluens (Mushroom) Extract: Visibly smooths, calms, and promotes youthful-looking skin.

Ingredient Callouts: Free of parabens, formaldehydes, formaldehyde-rele

$79.00

Best brown spot treatment money can buy...Not for the faint of heart but if you have serious age spotting issues this treatment is for you. I am a very fair sun loving 45 year old who suffers from a never ending emergence of brown spots. ...I absolutely loved the major fade dark spot kit, I honestly used only once and saw a world of difference, I have dark spots and once I finished the products my dark spots super faded.

What it is: A dark spot and discoloration-fighting trio, including an AHA mask, brightening serum, and vitamin C moisturizer, for smooth, even, and glowing skin.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dark Spots, Redness, Dullness


Highlighted Ingredients:

- Vitamin C Ester (Tetrahexyldecyl Ascorbate): Brightening agent and antioxidant.

- Glycolic Acid: Exfoliates and promotes smoother skin.

- Alpha Arbutin: Improves the appearance of uneven skin t

$57.00

I love the the Pre-Show Glow Instant Retexturizing Treatment. I used this product twice a week and can see an improvement in my skin’s dark spots and vibrance. ...The product leaves your skin feeling silky smooth! I have acne prone skin with dark spots and this seems to have improved the spots thus far!

What it is: This one minute 10% AHA treatment clarifies, purifies, brightens and smooths skin by gently clearing dull surface cells to even texture over time.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dark Spots, Dullness, and Uneven Texture


Formulation: Liquid

$94.00

This makes it a fantastic option for those with sensitive skin or anyone new to retinol treatments. Overall, the CLINICAL 0.3% Retinol + 2% Bakuchiol Treatment has exceeded my expectations. ...Best retinol in the market!...I also noticed my acne scars looked brighter than before and my pores look visibly smaller which is a huge deal for me!

What it is: A retinol-, bakuchiol-, and peptide-powered formula that supports skin's natural elasticity, reduces the look of lines and wrinkles, and addresses loss of firmness.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Fine Lines and Wrinkles, Pores, and Loss of Firmness and Elasticity

Formulation: Lightweight Cream

Highlighted Ingredients:
- Retinol 0.3%: Reduces the look of fine lines and wrinkles.
- Bakuchiol 2%: Amplifies retinol's visible effect on skin.
- Peptides: Support natural elasticity and visibly firm skin.

Ingredient Callouts: Free of parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone, coal ta

$57.00

Dennis Gross’s Advanced Retinol + Ferulic Perfectly Dosed Retinol Treatment is a skincare game-changer. LAfter four weeks, I noticed reduced dark spots, smoother texture, and increased radiance. ...Wow! This retinol treatment is a game-changer. My fine lines and dark spots are visibly reduced, and my skin texture is smoother.

What it is: A targeted, overnight peel treatment to reduce fine lines, improve uneven tone and texture, and restore hydration for a radiant, healthy-looking complexion.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dark Spots, Fine Lines and Wrinkles, and Uneven Texture


Highlighted Ingredients:

- Retinol: A vitamin A derivative that supports collagen production while visibly reversing signs of photo-aging, improving fine lines and wrinkles, addressing UV-induced free-radical damage, reducing blemish-causing sebum, and fading dark spots.

$117.00

This overnight wrinkle treatment from Dr dennis Gross is a holy grail of wrinkle treatments!! ...I have some fine lines around my eyes and mouth when I smile, I have uneven skin tone and a few acne marks/ dark spots, I was so shocked at how amazing my skin looks now the fine lines have disappeared my skin tone has evened out a lot and my acne scars and dark spots has drastically lighten I’m so impressed by this overnight wrinkle treatment that I’m definitely adding this to my skincare routine it’s amazing and it didn’t cause any irritation or break me out.

What it is: A hydrating, irritation-free, overnight retinol treatment that visibly firms and reduces the look of wrinkles.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Fine Lines and Wrinkles, Dryness, and Loss of Firmness and Elasticity


Highlighted Ingredients:

- Retinol: A vitamin A derivative that supports collagen production while visibly reversing signs of photo-aging, improving fine lines and wrinkles, addressing UV-induced free-radical damage, reducing blemish-causing sebum, and fading dark spots.

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“Best acne treatment ever Its not drying out the skin like other acne treatments do This is very gentle on skin but tough on acne I love it”
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“I love how easy and simple this is to use compared to other treatments as I don’t have to wash it off and it does all the work while I’m sleeping, it’s definitely a win”
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“This is honestly the best acne spot treatment out there. I’ve tried a lot of spot treatments, like the hydrocolloid patches, and this is better”
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“I have some fine lines around my eyes and mouth when I smile, I have uneven skin tone and a few acne marks/ dark spots, I was so shocked at how amazing my skin looks now the fine lines have disappeared my skin tone has evened out a lot and my acne scars and dark spots has drastically lighten I’m so impressed by this overnight wrinkle treatment that I’m definitely adding this to my skincare routine it’s amazing and it didn’t cause any irritation or break me out”
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“But honestly, after just one night, I woke up to a noticeably reduced pimple—it was basically gone. If you want a quick, effective way to treat pimples overnight, this patch really works”
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“I am so excited to include the First Aid Beauty Body Acne Clearing Mist in my routine for my body acne and strawberry legs.This mist is exactly what I've been looking for”
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“Unlike some other retinoid treatments, the Equilibrium Resurfacing Retinoid Treatment does not cause irritation or redness, making it suitable for most sensitive skin types.I have noticed a significant improvement in the overall texture and tone of my skin”
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“I received this product for free in exchange for my honest review I've been using this product for about a week (3 times within that time) Pros- my face looked noticably brighter Cons - i got pimples and the product didnt mix well with my sunscreen Im not sure if the pimples are a sign of my skin purging from using a new product”
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“1st review….As someone in their 60s, who doesn’t very often get pimples. I got a pimple with a big white head on it, and I use this product and within hours the whitehead had reduced and the pimple had flattened”
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“I have to say I am so impressed! I have oily acne prone skin. My skin is less red, active breakouts are healing faster and my post acne marks are fading”

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