Best Acne Spot Treatments

Sephora customers often prefer the following products when searching for Best Acne Spot Treatments.

Acne is be a pesky and stubborn skin concern that many of us have experienced at some point in our lives. Whether it's a sudden breakout or a lingering blemish, finding an effective spot treatment is crucial for targeting those unwelcome visitors. We understand the frustration and the desire to find the best acne spot treatments that deliver quick and noticeable results. That's why we've curated a comprehensive list of acne-fighting products, so you can confidently choose the treatment that suits your skin needs. From powerful ingredients to innovative formulations, we'll explore the top options available to help you bid farewell to those pesky pimples and regain your confidence.


I usually get very dry with acne spot treatments, but this one worked well. I would recommend....One of the BEST acne spot treatments that I have ever used!!

What it is: A rapid-action formula with two percent salicylic acid to fight breakouts and visibly improve blemish-prone skin in as little as 24 hours.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Oiliness, and Acne and Blemishes

Formulation: Gel

Highlighted Ingredients:
- Salicylic Acid: Unclogs pores and targets breakouts.
- Glycolic Acid: Visibly resurfaces skin and discourages the appearance of post-acne marks.
- Aloe: Calms, soothes, and nourishes skin.

Ingredient Callouts:
This product is vegan, cruelty-free, and comes in recyclable packaging.


Best Acne Spot Treatment!...This is honestly the best acne spot treatment out there. I’ve tried a lot of spot treatments, like the hydrocolloid patches, and this is better. ...It's not drying like some of the other acne spot treatments. It goes on really smoothly and you just need the tiniest of amounts.

What it is: A non-drying, gentle, and targeted acne treatment that clears acne spots fast while layering under makeup without flaking.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Redness, Acne and Blemishes

Highlighted Ingredients:
- 2% Succinic Acid: Visibly reduces blemish size and absorbs excess oil.

- 2% Sulfur Powder: Absorbs excess oil and unclogs pores for clearer-looking skin—long term.

- 1% Salicylic Acid: Gently exfoliates the skin, reducing dead-skin cell buildup.

Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

Mario BadescuDrying Lotion

Size: 1 oz/ 29 mL·ITEM: 2184992

Type: Original

442 Reviews


Good spot treatment for acne prone normal/dry skin...Really great for spot treatments! Gets zits down to a manageable size overnight....FAVORITE SPOT TREATMENT...It dries your acne spot without irritating or drying your skin.

What it is: An original, award-winning solution that dries up surface blemishes overnight.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Lightweight Liquid

Highlighted Ingredients:
- Salicylic Acid: Exfoliates to help shed pore-clogging dead skin cells.
- Sulfur: Cleanses pores and absorbs excess oil.
- Calamine: Delivers a cooling, soothing effect.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone, coal tar, hydroquinone, triclosan, and triclocarban, and contains less than one percent of synthetic fragrances.


I've tried a lot of acne spot treatments and this has been the only thing so far that has significantly helped....Best spot treatment!...I am IN LOVE with this! I have used other acne spot treatments and all they did was dry out the spot and leave the blemish.

What it is: A topical formula for breakouts with results as good as a leading prescription.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Lightweight Gel

Highlighted Ingredients:
- Salicylic Acid: Clears dead skin cells that can contribute to clogged pores.
- Witch Hazel: Minimizes shine on the skin‘s surface and tightens the appearance of pores.
- Laminaria Saccharina Extract: Helps decrease oil buildup that can lead to breakouts.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates. This product is also gluten-free.

What Else You Need to Know: This formula with salicylic acid helps clear th


Drying aside I do notice a difference with this product and keep it around as I like to rotate spot treatments since they often times can stop working. ...It works for my acne spot.

What it is: A five percent benzoyl-peroxide-based treatment that targets pores to diminish the appearance of existing blemishes and blackheads, and absorb excess oil.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Uneven Texture, Acne and Blemishes, and Oiliness

Formulation: Lightweight Lotion

Highlighted Ingredients:
- Five Percent Benzoyl Peroxide: Helps diminish the look of blemishes.
- Advanced Liposomes: Help protect skin from environmental aggressors, alleviate dryness, and prevent excess water loss.
- Argan, Saw Palmetto, and Sesame Seed Extracts: Absorb excess oil.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates.


I've been using this for years. Simply THE best acne spot treatment around....Dries pimple quicker than other treatments I’ve tried before. It is a bit pricey for the size but it is the same for other acne spot treatments.

What it is: An acne treatment gel with 1.5% Salicylic Acid for on-the-spot, targeted treatment––wherever you go.

Skin Type: Normal, Dry, and Oily

Skincare Concerns: Acne and Blemishes, Redness, and Oiliness

Formulation: Gel

Highlighted Ingredients:

- Saw Palmetto: Helps control oil, reduce shine, and prevent breakouts.

What Else You Need to Know: This blemish-fighting formula with saw palmetto and 1.5 percent salicylic acid helps eliminate excess oil that can lead to break outs.


Best acne spot treatment I have ever used!...Better than any other acne spot treatments I've used!...I’ve used plenty of different acne spot treatments, and always end up coming back to these dots!

What it is: The only patented acne patch that combines clean hydrocolloid polymer technology and actives to minimize the look of pimples overnight.


this has been on of the only spot treatments that has worked for my acne!...It works! One of the few acne spot treatments I’ve tried that works! A bonus is that it doesn’t leave the blemish dry and flaky.

What it is: A fast-acting blemish spot treatment that zaps pimples overnight with zero irritation and helps brighten the look of spots from past breakouts.

Skin Type:
Normal, Dry, Combination, and Oily

Skincare Concerns: Acne/Blemishes and Oiliness

Highlighted Ingredients:
- Clay and Sulfur: Absorb excess oil and balance sebum production.
- Willow Bark: Nature's alternative to salicylic acid, it helps calm breakouts and clear pores.
- Azelaic Acid: Helps prevent spots left by past blemishes.

Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

Peace OutSalicylic Acid Acne Day Dots

ITEM: 2644128

Size: 1 pack / 20 dots

1.3K Reviews


Just your basic acne spot treatments. I like that you wear them overnight and they do seem to make a difference!...A must have for my acne spot treatments...After a few weeks of using it, I did notice a slight difference on my acne when it started to occur on my chin. This is a must have in your acne treatment bag.

What it is: Our thinnest, sheer acne patch for virtually invisible wear, alone or under makeup, with acne-fighting actives to minimize the look of pimples


I use retinol on alternate nights, followed by a moisturizer. This treatment has significantly lightened some of my acne spots and has improved my skin texture overall....I am an avid retinol user and this retinol treatment is effective and gentle. I get super dry and my skin peels when I use other retinol treatments but this Paula's choice retinol treatment is perfect for me.

What it is: An advanced 1% retinol formula with skin-supportive peptides and vitamin C, smooths wrinkles and firms skin to reduce visible signs of aging.   

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Fine Lines and Wrinkles, Pores, and Loss of Firmness and Elasticity

Formulation: Lightweight Cream

Highlighted Ingredients:
- Retinol (Vitamin A) 1%: A potent, slow-release concentration that visibly improves signs of aging.

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