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Sephora customers often prefer the following products when searching for Spot Acne Treatments.

Browse the top-ranked list of Spot Acne Treatments below along with associated reviews and opinions.

Size 0.33 oz/10 mL · ITEM 2021046
exclusive· limited edition· buzzworthy· online only
$16.00

So good!...Best stuff...I have stubborn acne flairups once a month that get huge and stay for over a week and with this twice a day on clean skin it keeps my blemish small and it goes away in 2 days!!...It is slightly drying, but since it's a spot treatment it's not so bad.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive

What it is:
An acne treatment gel with a proprietary skin-recovery complex to clear breakouts quickly and promote balanced, smooth skin with no redness, dark spots, or scarring.

Solutions for:
- Acne and blemishes
- Pores
- Redness

If you want to know more…
This formula gently and effectively treats visible acne overnight using a skin-recovery complex that blends salicylic acid, vitamin B3, azelaic acid, caffeine, and other complexion clearers. The formula helps fight redness and unclog pores while calming and soothing post-breakout skin. The result is a clarified, glowing complexion free of redness, dark spots, and hyperpigmentation.

What it is formulated WITHOUT:
- Parabens
- Phthalates

What else you need to know:
This product is dermatologist tested, hypoallergenic, vegan, and fragrance-free.
Size 0.68 oz/ 20 mL · ITEM 1989318
exclusive· limited edition· buzzworthy· online only
$28.00

Love it!...Thank you!...I think it'll last a long time because you only need to use a little bit....Best Spot Treatment
Which skin type is it good for?
✔ Oily
✔ Combination

What it is:
A spot treatment that targets problem areas on contact to help clear blemishes.

Solutions for:
- Oiliness
- Acne and blemishes

If you want to know more…
Breakout Control Targeted Acne Spot Treatment effectively targets acne and blemishes at the source. Salicylic acid refines skin texture and possesses anti-bacterial properties to suppress acne-causing bacteria, oil-absorbing ginger root extract delivers gingerols to soothe skin, and frankincense helps reduce sebum production.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
This product was inspired by the original Blue Astringent Herbal Lotion formulated in 1964, and is tested under dermatologist supervision. As part of your acne-free skincare routine, start using the Blue Herbal Gel Cleanser, followed by the Blue Astringent Herbal Lotion and Blue Herbal Moisturizer.

Kiehl’s is inspired by its rich heritage as an old-world apothecary, applying over 165 years’ worth of cosmetic, pharmaceutical, herbal, and medicinal knowledge into the formulations. They utilize the finest natural ingredients and incorporate advanced scientific technologies to ensure the highest quality and most efficacious formulas without compromise. They are protective of the environment as they maximize the use of renewable, sustainable, and biodegradable ingredients. Kiehl’s proudly stands behind the quality, efficacy, and safety of each of their products.
Size 1 oz/ 30 mL · ITEM 1592831
exclusive· limited edition· buzzworthy· online only
$27.00

IN LOVE...Love it...I just finished a small bottle of this, which lasted a little over a month (would last much longer if used as just a spot treatment, but a slather this stuff all over my face)....It won't prevent acne but when you notice your acne is starting up, just "nuke it"(apply lightly) with this stuff twice a day on the spot and it should prevent your acne from getting really bad.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry

What it is:
A daily treatment gel for acne-clearing results equal to a leading topical prescription.

Solutions for:
- Acne and blemishes
- Pores
- Oiliness

If you want to know more…
This ultra-powerful daily treatment gel is powered by Clinique’s four-in-one clearing complex with salicylic acid to start clearing blemishes instantly and help prevent new ones from forming. You can make visibly clearer skin a way of life.

What it is formulated WITHOUT:
- Parabens

What else you need to know:
This product is allergy tested, non-acnegenic, and free of oil and fragrance.

This product is an Allure Best of Beauty award winner.
Size 0.5 oz/ 15 mL · ITEM 1592856
exclusive· limited edition· buzzworthy· online only
$18.00

Spot on!...WORTH IT...This is the BEST acne spot treatment that I have ever used!...This is perfect as a spot treatment for all of the above.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry

What it is:
A daily treatment gel for acne-clearing results equal to a leading topical prescription.

Solutions for:
- Acne and blemishes
- Pores
- Oiliness

If you want to know more…
This ultra-powerful daily treatment gel is powered by Clinique’s four-in-one clearing complex with salicylic acid to start clearing blemishes instantly and help prevent new ones from forming. You can make visibly clearer skin a way of life.

What it is formulated WITHOUT:
- Parabens

What else you need to know:
This product is allergy tested, non-acnegenic, and free of oil and fragrance.

This product is an Allure Best of Beauty award winner.
ITEM 1962141
exclusive· limited edition· buzzworthy· online only
$19.00

SO GOOD...Love it...Aside of acne spots treatments that failed us there was a time a couple of years when acne dots spot treatments came about and yes they were really helpful but wasn't quiet perfect until these acne dots came about....ook so they're good but there are a few things, they work super well on a forming spot absolutely no fault there but if you're like me and you pick at you're skin I wouldn't bother with them they do not work that way but if you're looking for them for forming spots then they're excellent.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive

What it is:
A breakthrough blemish-healing dot that combines hydrocolloid technology with active anti-acne ingredients to minimize breakouts overnight.

Solutions for:
- Acne
- Pores
- Redness

If you want to know more…
These patent-pending acne dots are the first and only treatment to combine hydrocolloid technology with blemish-fighting actives. Infused with salicylic acid to kick acne-causing bacteria to the curb, they also contain vitamin A to help support natural skin turnover and aloe vera to soothe redness. Hydrocolloid technology extracts impurities while creating a protective barrier that guards against external irritants. By protecting your blemishes from bacteria, inflammation, and picking, these dots also reduce the potential for acne scarring. Whether you're struggling with hormonal acne, whiteheads, or inflamed pimples, your blemish is less red, less painful, and significantly less irritating in as little as six hours.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
Peace Out Acne uses hydrocolloid technology—a soothing, absorbent, waterproof bandage used for decades by doctors to speed skin healing. This innovative material gently extracts impurities, protects skin moisture, and creates a protective barrier against irritants. While hydrocolloid technology has been used for years to treat acne, these dots are the first to combine the healing power of hydrocolloid bandages with active anti-acne ingredients. The addition of blemish-fighting extracts creates the ideal environment for speedy relief from breakouts. These Acne Healing Dots effectively adhere to the skin (without causing irritation) and deliver a powerful dose of anti-acne ingredients while keeping the skin hydrated and comfortable for hours. They are latex-free, cruelty-free, and noncomedogenic.
Size 1 oz · ITEM 1167147
exclusive· limited edition· buzzworthy· online only
$26.00

I win....Love it...overall one of the best acne treatments I've tried, acne was diminished and more healed the next day after trying it, still works on dryer patches of acne without any flaking for me personally but could have a more drying affect upon someone less oily than me, overall really good product...I just hate that you have to dip a cotton swap into it because I feel like so much of the solution is wasted... BUT, I've had this bottle for at least a month now and I feel like it's going to last me a while, which is good.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry

What it is:
An effective blemish-fighting acne treatment to minimize pimples, zits, and help prevent future breakouts.

Solutions for:
- Acne/blemishes
- Pores

If you want to know more…
Kate's bestselling EradiKate™ Acne Treatment is specifically formulated with the highest level of sulfur allowed to effectively fight blemishes, reduce acne, and help keep skin free of new breakouts. AHAs are designed to reduce the appearance of enlarged pores while zinc oxide, a natural mineral, provides oil control by absorbing excess sebum. The result is clearer skin that lasts.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
EradiKate Acne Treatment is most effective when applied to affected areas as soon as blemishes or pimples are noticed.

"Do you have a pimple you can feel but can't see? Use EradiKate on the area immediately to help prevent it from surfacing."—Kate Somerville, Founder
Size 4 oz/ 120 mL · ITEM 1906106
exclusive· limited edition· buzzworthy· online only
$38.00

so good...It's ok...The EradiKate Daily Cleanser Acne Treatment, is better at cleansing and removing makeup compared to getting rid of acne Positives- Prevent future acne from occurring no smell helps fade scars Negatives- pink does not get ride of acne dries out skin if over-used I tried this product for about two month and did not see any decrease in my acne, and no new acne....I do have to say that as soon as I applied it it burnt like a b but after a few hours I was completely astonished at how much my acne has been disappearing!
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination

What it is:
A daily foaming acne cleanser that promotes visibly clearer skin without drying.

Solutions for:
- Acne and blemishes
- Oiliness
- Pores

If you want to know more…
This powerful, medicated cleanser delivers a luxuriously whipped texture and three percent sulfur to address acne and blemishes, draw out impurities, and target congested pores. Honey and rice bran extracts calm redness, while natural oat extract addresses excess sebum. With continued use, this gentle, yet effective daily cleanser leaves skin clearer with visibly minimized pores.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates
Size 2 oz · ITEM 1694173
exclusive· limited edition· buzzworthy· online only
$54.00

LOVE IT...No joke!...Alright, I work at Sephora but this is not a "wow buy this cause it works" this is a "wow this is the best mask I've tried in a long time" and I mean it....Not only does it visibly reduce acne after a couple uses, it makes skin feels smooth, firm, soft and polished.
What it is:
An innovative, gel-cream mask that helps clear acne breakouts, dissolve impurities, and minimize the appearance of pores without over-drying skin.

What it is formulated to do:
EradiKate™ Mask Foam-Activated Acne Treatment gently exfoliates dead skin cells and helps unclog pores while sulfur reduces the appearances and helps prevent pimples, zits, and future breakouts. Within minutes Kate’s unique foam-activated technology penetrates to help dissolve impurities and dirt, and address oily skin. An advanced botanical complex of boswellia serrata, honey extracts, and rice bran work to calm and soothe skin. Use this mask with Kate Somerville’s bestselling EradiKate Acne Treatment for an acne regimen that promotes a clearer complexion.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
This product is a CEW Beauty Insider Award winner for Best Acne Treatment in Prestige.

Research results:
In an independent clinical study after just 1 week:
- Women showed an 88% reduction in the number of blackheads
- Women showed a 55% reduction in the number of whiteheads
- 100% of women showed a reduction in pore size

After 4 weeks:
- Women showed a 100% reduction in the number of blackheads
- Women showed a 86% reduction in the number of whiteheads
- 100% of women showed a reduction in pore size
- 80% of women reported it prevents clogged pores to minimize breakouts
- 77% of women reported it absorbs excess oil
- 87% of women reported skin looked and felt smoother
Size 1 oz/ 30 mL · ITEM 2113777
exclusive· limited edition· buzzworthy· online only
$58.00

Love it!...In love!...Usually salicylic acid doesn't do a lot for my acne spots but this one is a keeper and my new go to!...I have pretty oily skin and gets lot of breakouts and redness around my nose and chin, and after using this for just a few days at night my skin looks a lot more even and no new pimples!
Which skin type is it good for?
✔ Normal
✔ Combination

What it is:
A lightweight, all-over acne treatment, formulated with salicylic acid to reduce and prevent blemishes.

Solutions for:
- Acne and blemishes
- Dullness and uneven texture
- Pores

If you want to know more…
This lightweight, all-over acne treatment clears acne with two percent salicylic acid—the highest percentage allowed. It also contains retinol, which helps smooth the look of skin texture and even the look of skin tone while a blend of soothing ingredients helps balance the skin’s microbiome. This hydrating formula also contains sodium PCA and sodium hyaluronate, which moisturize skin and help offset dryness that could be caused by salicylic acid and/or retinol.

Research results:
In an independent clinical study, after 24 hours/overnight:
- 97% of subjects showed improvement in the appearance of pore size
- 90% of subjects showed improvement in the appearance of skin texture
- Blackheads were significantly improved
- Pustules were significantly improved

After 4 weeks:
- 100% of subjects showed improvement in appearance of pore size
- 100% of subjects showed improvement in the appearance of skin texture
- 79% of subjects showed improvement in whiteheads
ITEM 1778364
exclusive· limited edition· buzzworthy· online only
$22.00

Works but......Wow you guys!...Sulfur spot treatment is really the only thing that has actually gotten rid of my pimples so I was without a spot treatment solution while traveling until I discovered this....Also, it has a strong sulfur smell and leaves a slight pinkish color where applied, so it's best to use at night or when you won't be going out.
What it is:
A bestselling blemish banisher now in individually wrapped, pre-treated swabs.

What it is formulated to do:
This powerful pink acne treatment is formulated with 10 percent Sulfur—the highest level allowed to effectively fight acne—to help clear skin of blemishes and acne-causing bacteria. It also contains AHAs to reduce the appearance of enlarged pores and help control sebum production. This acne treatment also prevents future breakouts, resulting in a clearer complexion.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
"Do you have a pimple you can feel but can't see? Use EradiKate on the area immediately to help prevent it from surfacing."—Kate Somerville, Founder
ITEM 1953009
COLOR: Pink [ 2 more colors ]
exclusive· limited edition· buzzworthy· online only
$149.00

Not bad...love it!...List night I could feel a spot that would eventually become a pimple ( it hurt but the skin was smooth), applied the device to that spot 3 times, still woke up to a risen pimple head....I've noticed that if I catch a spot early-on, and immediately treat it 2-3 times consecutively with my Espada, the pimple heals either the next day or the whitehead comes up and clears within 2-3 days, which is a huge improvement from how long I usually wait out a pimple (a week or more).
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive

What it is:
A blemish-busting tool that combines ultra-powerful blue light and T-Sonic™ pulsations to tackle acne-causing bacteria.

Solutions for:
- Acne and blemishes

If you want to know more…
Espada Acne-Clearing Blue Light Pen features blue light and T-Sonic pulsations to target acne-causing bacteria—delivering a painless, non-invasive spot treatment in as little as 30 seconds. The pulsations begin when the device is placed on the skin, supporting natural blood microcirculation and facilitating the skin's renewal, and gradually increase in speed until the 30 second cycle is finished. The ultra-hygienic silicone surface inhibits growth of bacteria on the device itself.

What else you need to know:
This tool is FDA-approved. Espada, which means sword in Spanish, effectively targets acne and blemishes on the skin’s surface.
Size 1.7 oz/ 50 mL · ITEM 2070944
exclusive· limited edition· buzzworthy· online only
$44.00

Love it...LOVE IT!...I believe that this product does a good job of keeping new acne at bay, but it doesn't really get rid of acne that's already there....use the Murad Outmart Acne Badge treatment for a week without interruption and the results were favorable and visible in a short time.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination

What it is:
A powerful treatment with five clinically proven acne-clearing acids to clear existing acne and help prevent future breakouts.

Solutions for:
- Acne
- Oiliness
- Pores

If you want to know more…
This medicated lightweight gel serum is clinically proven to reduce overall acne in just one week. Salicylic acid combines with lysophosphatidic, hydroxydecanoic, sebacic, and glycolic acids in penta-acid technology to clear skin of acne-causing bacteria, oiliness, and blackheads while minimizing dryness and irritation.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
Five acids. Clear skin. Proprietary penta-acid technology is salicylic acid combined with lysophosphatidic, hydroxydecanoic, sebacic, and glycolic acids to reduce pimples, blackheads, and whiteheads. This product is non-irritating, non-drying, and free of gluten, alcohol, and animal-derived ingredients.

"I have seen many patients develop a tolerance to prescription acne treatments, and when they stop working, it’s devastating. Treating acne demands a more holistic approach that includes lifestyle, nutrition, and advances in topical skincare. I developed Outsmart Acne™ Clarifying Treatment to be used as part of a whole-person regimen to help skin stay consistently clear."—Howard Murad, M.D., FAAD

Murad is cruelty-free, and is proud to deliver high-performance formulas that are tested on people, not animals.

Research results:
In clinical expert grading:
- 96% of subjects had reduced pimples, blackheads, and whiteheads in just 1 week
Size 5 oz/ 150 ml · ITEM 1989292
exclusive· limited edition· buzzworthy· online only
$22.00

ehhh it's ok...Beyond efficient...I've been using this one at night and a gentle cleanser in the morning & my skin has yet to become dry!...I have oily acne prone skin and this has a nice tingle once applied.
Which skin type is it good for?
✔ Oily
✔ Combination

What it is:
A high foaming acne cleanser that helps purify pores, removing traces of dirt and oil.

Solutions for:
- Oiliness
- Acne and blemishes

If you want to know more…
Inspired by the iconic Blue Astringent Herbal Lotion formulated in 1964, this oil-fighting cleanser is formulated to help clear blemishes, pimples, blackheads, and whiteheads, and prevent new ones from forming. It contains salicylic acid to penetrate deep into pores.

What else you need to know:
This product is tested under dermatologist supervision.

Kiehl’s is inspired by its rich heritage as an old-world apothecary, applying over 165 years’ worth of cosmetic, pharmaceutical, herbal, and medicinal knowledge into the formulations. They utilize the finest natural ingredients and incorporate advanced scientific technologies to ensure the highest quality and most efficacious formulas without compromise. They are protective of the environment as they maximize the use of renewable, sustainable, and biodegradable ingredients. Kiehl’s proudly stands behind the quality, efficacy, and safety of each of their products.
Size 1.7 oz/ 50 g · ITEM 1901230
exclusive· limited edition· buzzworthy· online only
$59.00

Wow !...in LOVE...amazing, kinda has a light medicinal smell which I love, works well to reduce redness and pimples (I have cystic acne and when I wear it as a spot treatment at night they reduce in size and even disappear in 3-4 days) gave 4 stars though because it dries up in the jar VERY quickly and leaves weird chunky flakes....I got a few samples of this mudmask to try first because is very expensive ,i think is a good mask but make sure you use it for at least a week evry day to see if it works on your skin I deffinetely saw a difference in my pore size and also it took lot of the sebum out of my black heads .
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination

What it is:
A skincare mask designed to visibly clear the complexion.

Solutions for:
- Pores
- Acne and blemishes
- Oiliness

If you want to know more…
SEXY SKIN FOR EVERYONE! NEW SIZE! NEW PRICE!

The SUPERMUD® Clearing Treatment was developed to address common skin concerns, which include blemishes, redness, scars, razor bumps, and in-grown hair. The potent mud formula supports skin’s natural oil balance, while a proprietary blend of six acids (glycolic acid, salicylic acid, lactic acid, mandelic acid, pyruvic acid, and tartaric acid) works to help minimize pores and create clearer skin. Activated-X charcoal lifts away dirt and other skin congestions, resulting in a refined, healthy-looking complexion.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
SUPERMUD is now offered in a 50 g jar—which is 45 percent more for the same price.

This product is an Allure Reader’s Choice award winner.

Research results:
In a consumer study on a number of participants, after 1 day:
- 94% felt their skin looked renewed
- 91% saw an improvement in skin clarity
- 94% felt the product gently cleared their skin

After 3 uses over 7 days:
- 98% reported their skin looked renewed
- 97% saw an improvement in skin clarity
- 97% felt the mask gently cleared their skin
Size 1 oz/ 30 mL · ITEM 1418581
exclusive· limited edition· buzzworthy· online only
$105.00

A WOW!...New fav...I got a facial at Sephora with good geans and the UFO face oil mixed together and noticed a huge difference in my skin a few hours latter I suffered from redness on my check bones and dark spots from pass acne theses two products made my skin so clear and bright I was amazed the redness had completely gone away my skin looked soft and smooth the dark spots had faded and my skin had such a clear Complexion even my pores had tightened up I'm in love thanks Sunday Riley for makeing me feel beau...I got a sample with my order and I tried on after my black mask and the results were amazing, the next day everybody gave me complements on my skin I have sensitive skin and I love this product I went back to sephora store and got me a full size, I love this stuff I use it only at night my skin feels great the next morning looks amazing between my clarasonic, the sunday riley face wash and the good genes treatment my skin looks awesome.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry

What it is:
A clarifying, line smoothing lactic acid treatment.

Solutions for:
- Dullness and uneven texture
- Dark spots
- Fine lines and wrinkles

If you want to know more…
Good Genes All-In-One Lactic Acid Treatment is formulated with high potency, purified grade lactic acid that immediately exfoliates dull, pore-clogging dead skin cells, revealing smoother, fresher, younger-looking skin. Fine lines appear visually plumped while the skin looks more radiant. With continued use, the appearance of stubborn hyperpigmentation and the visible signs of aging are reduced for a healthier-looking complexion. Perfect for all skin types and all ages, this treatment is enhanced with licorice for brightening, Good Genes clarifies, smooths, and retexturizes for instant radiance.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
Backstage at NY Fashion Week, Sunday Riley combines two pumps of Good Genes and one pump of Ceramic Slip Clay Cleanser for a "flash facial." Leave on for one to 10 minutes for an immediately radiant, deep detox facial. This product is cruelty-free.

"As with any AHA, use a sunscreen to prevent sun sensitivity."—Sunday Riley

Research results:
Clinically tested and proven to significantly improve the appearance of lines and wrinkles in 3 minutes. Results obtained via profilometry analysis:
- 100% of women said their skin looked and felt significantly smoother and more radiant, with visibly reduced lines and wrinkles after application
- 100% of women said this was the most effective skin-plumping product they have ever used and would definitely recommend this product to a friend
Size 1.7 oz/ 50 mL · ITEM 1463801
exclusive· limited edition· buzzworthy· online only
$59.00

My fav...I Like...It is on the pricey side but believe me it is well worth it if you have large pores, blackheads, uneven skin tone, acne scars, etc.... for me it has helped all of these things and you notice a huge difference with first use if you have large and or clogged pores!!!...I use a muslin cloth with a regular face wash daily but let my skin renew itself so I don't overexfoliate (that aggravates acne if you suffer from it) so I let my skin heal, that means no scrubbing etc. just wash and mosturize, massage with hands only.
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry

What it is:
A professional-quality facial in a jar that softens and brightens in as little as 10 minutes.

Solutions for:
- Fine lines and wrinkles
- Dullness and uneven texture

If you want to know more…
SEXY SKIN FOR EVERYONE! NEW SIZE! NEW PRICE!

The YOUTHMUD™ Tinglexfoliate Treatment moisturizes, exfoliates, and lifts away impurities without disturbing skin’s essential oils. Antiaging ingredients brighten and smooth while delivering a tighter, more youthful appearance with visibly minimized pores.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

Research results:
In a consumer study, after 1 day:
- 97% agreed skin looked and felt smoother
- 91% reported brighter skin
- 94% experienced gentle surface exfoliation

After 3 uses, over 7 days:
- 100% agreed dull skin appeared brighter
- 97% reported gentle surface exfoliation