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Sephora customers often prefer the following products when searching for Supplements Over $50.

Browse the top-ranked list of Supplements Over $50 below along with associated reviews and opinions.

ITEM 654293
exclusive· limited edition· buzzworthy· online only
$50.00

Which skin type is it good for?
✔ Oily
✔ Combination

What it is:
A bottle of Internal Skincare® supplements for non-cystic acne-prone skin that provide the nutrients needed to support the body's natural defense against blemish-producing toxins.

Solutions for:
- Acne and blemishes
- Pores
- Oiliness

If you want to know more…
Murad's supplements are designed to improve the overall health of the skin. They are formulated with ingredients that help reduce non-cystic blemishes and provide internal defense against breakouts for clearer, healthier-looking skin.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
ITEM 1933092
exclusive· limited edition· buzzworthy· online only
$54.00

Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry

What it is:
A pack of supplements designed to help support natural cellular hydration levels for youthful-looking skin with a healthy glow.

Solutions for:
- Dryness
- Fine lines and wrinkles
- Dullness

If you want to know more…
Hydrate skin from within. Hydro-Glow Dietary Supplements are based on Murad’s Cellular Water Principle® and are designed to help support natural cellular hydration levels for youthful-looking, vibrant skin. Glucosamine creates a reservoir of moisture, while helping boost natural hyaluronic acid and collagen, while osmolytes help maintain optimal cellular hydration.*

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
A pioneer in a whole-person approach to beauty, health, and well-being, Dr. Murad has developed targeted Internal Skincare® to enhance your skincare results and give you healthy, glowing skin from the inside out.* Dr. Murad recommends using this product with Hydro-Glow Aqua Peel (sold separately) to boost your skin's hydration levels and enhance skin’s luminosity.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research results: In a Murad sponsored study after 6 weeks:
- 85% saw more supple, healthy-looking skin
- 82% saw more radiant skin
- 79% saw smoother, firmer skin with minimized lines
ITEM 1789510
exclusive· limited edition· buzzworthy· online only
$59.00

What it is:
A supplement that combats the visible signs of aging from the inside by reducing the appearance of fine lines and wrinkles and supporting natural collagen.*

What it is formulated to do:
This patented complex attacks aging from the inside out. Glucosamine, amino acid complex, and vitamin A work to support natural collagen and connective tissue and allow for healthy cell renewal for the appearance of improved strength, clarity, and tone.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
ITEM 1650191
exclusive· limited edition· buzzworthy· online only
$60.00

What it is:
A rare supplement from lingonberry seed oil, clinically shown to rejuvenate the skin and reduce the appearance of wrinkles.

Solutions for:
- Dryness
- Fine lines and wrinkles

If you want to know more…
Lingonberry seed oil is a Hum exclusive that has an exceptionally unique and concentrated balance of omega 3 alpha linolenic acid, omega 6 linoleic acid, and omega 9 oleic acid. Arctic Repair is also rich in gamma-tocotrienol, a strong antioxidant. It increases skin hydration and elasticity while reducing the appearance of fine lines and wrinkles.

What else you need to know:
Hum is an all-natural line of supplements, gummies, and powders with clinically researched ingredients that are sustainably sourced, non-GMO, and free of soy, gluten, artificial colors, and preservatives. We can’t readily access many essential beauty nutrients through diet alone. Your skin, body, and general appearance is often the first to suffer if there is a nutrient imbalance. Hum’s mission is to make you look and feel great with products that compliment your beauty routine from the inside out and provide long-term care, repair, and protection—all in one step.

This bottle contains 90 soft gels (a 30-day supply) that are suitable for vegans and vegetarians.

Research results:
In a 2012 study on the effects of lingonberry seed oil on skin, tested on 30 women for 3 months:
- Significant improvement in skin hydration
- Significant improvement in skin density and elasticity
- Significant decrease in skin roughness
ITEM 2122927
exclusive· limited edition· buzzworthy· online only
$64.00

Really helpful after a big meal - less sluggish feeling, more energy - will buy again.
What it is:
An enzyme supplement to support optimal digestion and absorption of nutrients from each meal.*

What it does:
This supplement includes 17 enzymes specifically designed for a women’s diet. It’s meant to aid in the digestion of fats, carbs, grains, dairy, fiber, protein, vegetables, and sugars (including alcohol). Taking these enzymes consistently may help diminish the visible signs of aging, so you’ll not only look better, but feel better too. This no-refrigeration-required formula is supercharged with superoxide dismutase, the enzyme that protects against free radicals, providing anti-aging and antioxidant benefits.*

This set contains:
- 90 x Capsules

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
This women's digestive enzyme supports natural reduction in gas and bloating after a meal, as well as energy levels, nutrient absorption from food, healthy digestion of gluten protein, and the breakdown of otherwise difficult-to-digest food.* It is gluten-free and GMO-free, and contains no milk, soy, wheat, shellfish, egg, tree nuts, peanuts, corn, or animal by-products.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
ITEM 2162436
exclusive· limited edition· buzzworthy· online only
$78.00

What it is: An effervescent tablet containing eight key greens with only 10 calories and no sugar that packs a nutritional punch and tastes great, too.

Highlighted Ingredients:
- Spinach: Has alkalizing properties and helps support a healthy aging process.*
- Wheatgrass: Supports red blood cell production and circulation, and calms redness.*
- Kale: Provides nutrition and calms redness.*

Ingredient Callouts: Free of sulfates SLS and SLES, and parabens and contains less than one percent of synthetic fragrances. This product is also vegan, cruelty-free, and gluten-free.

What Else You Need to Know: 8Greens features eight essential greens, straight from the farm: spinach, wheatgrass, kale, blue green algae, spirulina, chlorella, barley grass, and aloe vera.

Have you had something green today? 8Greens is perfect for late morning starts, the afternoon slump, and the days you don’t eat right.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Size 5.8 oz/ 165 g (30 packets) · ITEM 1897693
exclusive· limited edition· buzzworthy· online only
$80.00

What it is:
A great-tasting, dietary supplement drink powder, designed to help improve general well-being, digestion, and immunity.

What it is formulated to do:
This Super Greens Dietary Supplement features single-serving packets for on-the-go convenience. The super foods provide an instant boost of nutrition and contains Perricone MD’s proprietary NRF2 Antioxidant Support Complex™ as well as probiotics and phytonutrients. Infused with natural fruit flavors, it’s an easy, enjoyable way to get the vitamins and minerals that you need to perform at your best.

It helps support overall well-being and appearance of aging, supports the body’s natural antioxidant self-defense mechanisms, helps detoxify and nourish the body from the inside out, and helps defend against oxidative stress.*

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
Super Greens Dietary Supplement gives daily boost of nutrition with 11 vegetables: kale, parsley, spinach, wheat grass, broccoli, spirulina, barley grass, beet root, chlorella, alfalfa, cauliflower, green cabbage, and water cress.

One serving includes as much:
Vitamin C: four and a half tangerines
Vitamin A: two cups of lettuce
Riboflavin: four cups of spinach
Vitamin B6: four bananas
Folic acid: four cups of papaya

This product is free of GMOs, artificial colors, and preservatives.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
ITEM 1159961
exclusive· limited edition· buzzworthy· online only
$95.00

What it is:
Vitamin supplements that work from the inside out to support clear skin.

What it is formulated to do:
The Perricone MD Skin Clear Nutritional Support System program is one of the most advanced and comprehensive dietary supplements available to help improve the appearance of problem skin. It's specifically formulated to improve skin's clarity while providing toning benefits and improving skin's texture. This program also helps to support a healthy immune system and provide antioxidant protection.

What else you need to know:
Each box contains 30 packets of once-daily supplements; daily packet contains:
- B Complex + Vitamin C
- Evening Primrose Oil (EPO)
- Ascorbyl Palmitate
- Omega-3
- Ala+DMAE+Chromium+Zinc
- Tocospan Vitamin
- Calcium+Magnesium+Vitamin D supplement
ITEM 1160118
exclusive· limited edition· buzzworthy· online only
$155.00

What it is:
A program that works from the inside out to nourish and condition skin—resulting in a healthy, luminous glow.

What it is formulated to do:
Perricone Skin & Total Body Dietary Supplements is a perfectly dosed daily program of nutrients designed to support a healthy immune system and improve cognitive skills while enhancing the look and feel of your skin. Targeted nutritional supplements are an essential part of Dr. Perricone's 3-tier approach for a healthy body and beautiful skin and these supplements simultaneously support bone and joint function, fight free-radical damage, and stimulate healthy growth of hair and nails. They also help diminish the appearance of fine lines and wrinkles and give skin a radiant and glowing appearance.

This set contains:
60 packets with each containing: 3 Softgels, 2 Capsules, and 3 Caplets
- Perricone Prescription™ Super Antioxidant Formula (2)
- Omega 3
- Derma-Glo
- Rejuvenate
- Skin & Joint Essentials
- Calcium/Magnesium Blend
- Astaxanthin

What else you need to know:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research results:
- 86% reported improved skin texture
- 72% reported healthier skin appearance
- 65% reported lessening of crow's feet, lines, and wrinkles
ITEM 1160084
exclusive· limited edition· buzzworthy· online only
$42.00

What it is:
A supplement that helps to regulate weight and perfect skin.

What it is formulated to do:
Perricone MD Omega 3 Dietary Supplement is designed to elevate mood, regulate weight, and support cardiovascular health. It provides a multitude of benefits for the skin and the whole body.

What else you need to know:
This superstar of supplements is derived from wild sockeye salmon—the purest and most powerful resource of omega 3 and DMAE.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
ITEM 1678648
exclusive· limited edition· buzzworthy· online only
$40.00

What it is:
A vegan dietary supplement to help support metabolism and healthy blood sugar levels, naturally.*

If you want to know more…
The unique combination of caralluma fimbriata and 5-HTP helps curb appetite and decrease overall snacking, which may aid in weight loss. Chromium is a mineral that helps support healthy blood sugar levels, and green tea leaf extract helps support metabolism.*

What else you need to know:
Hum is an all-natural line of supplements, gummies, and powders with clinically researched ingredients that are sustainably sourced, non-GMO, and free of soy, gluten, artificial colors, and preservatives. We can’t readily access many essential beauty nutrients through diet alone. Your skin, body, and general appearance is often the first to suffer if there is a nutrient imbalance. Hum’s mission is to make you look and feel great with products that compliment your beauty routine from the inside out and provide long-term care, repair, and protection—all in one step.

This bottle contains 90 capsules (a 30-day supply) that are suitable for vegans and vegetarians.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Size 2 oz/ 60 mL · ITEM 2027886
exclusive· limited edition· buzzworthy· online only
$39.00

Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination
✔ Dry
✔ Sensitive

What it is:
A gluten-free, ingestible, detoxifying supplement formulated to rejuvenate the skin by boosting the body’s natural defense against the aging effects of free radicals from the inside out.

Solutions for:
- Free radical damage
- Damage caused by pollution
- Premature signs of skin aging

If you want to know more…
This ingestible supplement is formulated with an antioxidant powerhouse trio of green tea, white tea, and grape seed extract designed to fight the destructive effects of free radicals from within, helping to keep the complexion rejuvenated and restored.* Studies have shown that green tea, white tea, and grapeseed contain among others, the polyphenol EGCG (Epigallocatechin gallate), the strongest of any known form of anti-oxidants. EGCG is more than 100 times as effective at neutralizing free radicals as vitamin C and 25 times more powerful than vitamin E*.

Dr. Brandt’s signature antioxidant blend is also combined with maqui berry extract, a superfruit with the highest known ORAC (Oxygen Radical Absorbance Capacity), and goji berry extract, rich in anti-oxidants, vitamins, nutrients, and amino acids. These clarifying agents help support the body’s natural defenses against aging free radicals. Each dropper full is equivalent to the polyphenol content of 15 cups of green tea. With a light, tea-like taste, the drops can be added to your favorite beverage or meal from water and smoothies to oatmeal and salads for a daily boost*.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
No matter how diligent you may be about applying anti-oxidant-rich creams and serums, the painful truth is that we all will still fall victim to free radicals. Why? While UV rays, pollution, and other environmental aggressors set free radicals into motion externally, stress, lack of sleep, poor diet, and hormones also contribute. So without an internal line of antioxidant defense, your skin may still be susceptible to free radical attack.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Size 1.5 oz/ 42.5 g · ITEM 2008688
exclusive· limited edition· buzzworthy· online only
$38.00

What it is:
An adaptogenic blend of transformative superherbs and pearl that help combat the effects of stress to expand your beauty, luster, and glow from within.*

If you want to know more…
This formula contains ingredients that help the body to preserve collagen protein*, enhance elasticity of the skin*, and cope with stress* with a tart berry flavor. Moon Dusts are fresh and potent with intensely herbal flavors. You will feel the effects and your palate will evolve. Intensity has its benefits.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.

This product is cruelty-free and gluten free.
Size 1.5 oz/ 42.5 g · ITEM 2008720
exclusive· limited edition· buzzworthy· online only
$38.00

What it is:
An adaptogenic blend of lusty superherbs and Shatavari that help combat the effects of stress to ignite your creative energy, in and out of the bedroom.*

If you want to know more…
This formula contains ingredients that help support the body during stress*, provide energy, vitality, and well-being*, and boost libido* with a smoky, chocolaty flavor. Moon Dusts are fresh and potent with intensely herbal flavors. You will feel the effects and your palate will evolve. Intensity has its benefits.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.

This product is cruelty-free, gluten free, and vegan
Size 1.5 oz/ 42.5 g · ITEM 2008696
exclusive· limited edition· buzzworthy· online only
$38.00

What it is:
An adaptogenic blend of enlightening superherbs and supermushrooms that help combat the effects of stress to align you with the cosmic flow for great achievement.*

If you want to know more…
This formula contains ingredients that help sharpen focus and concentration*, increase mental stamina*, and promote a positive mind and mood.* The taste is herb forward with a botanical bite. Moon Dusts are fresh and potent with intensely herbal flavors. You will feel the effects and your palate will evolve. Intensity has its benefits.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.

This product is cruelty-free and gluten-free.
Size 1.5 oz/ 42.5 g · ITEM 2008704
exclusive· limited edition· buzzworthy· online only
$38.00

What it is:
An adaptogenic blend of tranquil superherbs and Chamomile Flower that help combat the effects of stress to soothe your tension for deep, nocturnal rest.*

If you want to know more…
This formula contains ingredients that help alleviate the effects of stress and tension* and promote more restful sleep* with notes of sweet, chamomile. Moon Dusts are fresh and potent with intensely herbal flavors. You will feel the effects and your palate will evolve. Intensity has its benefits.

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.
This product is cruelty-free, gluten free, and vegan. created with a blend of superherbs and chamomile flower that help combat the effects of stress to soothe your tension for deep nocturnal rest.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Size 1.5 oz/ 42.5 g · ITEM 2008738
exclusive· limited edition· buzzworthy· online only
$38.00

What it is:
An adaptogenic blend of uplifting superherbs and supermushrooms that help combat the effects of stress to expand peaceful awareness and align you with bliss.*

If you want to know more…
This formula contains ingredients that help promote a positive, relaxed state of mind*, increase resistance to stress, tension and irritability*, and enhance feelings of emotional well-being* with a Sweet, Nutty flavor. Moon Dusts are fresh and potent with intensely herbal flavors. You will feel the effects and your palate will evolve. Intensity has its benefits.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.

This formula is organic, cruelty-free, gluten free, and vegan.
Size 1.5 oz/ 42.5 g · ITEM 2008712
exclusive· limited edition· buzzworthy· online only
$38.00

What it is:
An adaptogenic blend of elite superherbs and supermushrooms that help combat the effects of stress to fuel your physical and entrepreneurial feats.*

If you want to know more…
Contains ingredients that help boost energy and reduce fatigue*, restore and sustain energy levels*, and support healthy cardiovascular function* with a neutral, earthy flavor. Moon Dusts are fresh and potent with intensely herbal flavors. You will feel the effects and your palate will evolve. Intensity has its benefits.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.

This product is organic, cruelty-free, gluten free, and vegan.
ITEM 1614858
exclusive· limited edition· buzzworthy· online only
$35.00

What it is:
A convenient month-long supply of daily vitamin packs combining Hum’s Red Carpet and Killer Nails formulas.

If you want to know more…
Runway Ready™ combines Red Carpet™ and Killer Nails™ in easy-to-take daily packs for glowing skin and strong nails.*

Red Carpet is designed to maximize hair's shine, minimize the appearance of pores, smooth the look of wrinkles, and enhance your natural glow. It works by combining the perfect balance of essential fatty acids, vitamins, and antioxidants to support the skin's glow with ample hydration and protection for skin and hair.*

Killer Nails is widely used for strong nails and hair, thanks to the key ingredient: biotin. Biotin is a water-soluble B-complex vitamin necessary for cell growth, as well as the production and metabolism of fat into amino acids. It has been specially formulated for Hum in this high-potency vegan formula.*

What else you need to know:
Hum is an all-natural line of supplements, gummies, and powders with clinically researched ingredients that are sustainably sourced, non-GMO, and free of soy, gluten, artificial colors, and preservatives. We can’t readily access many essential beauty nutrients through diet alone. Your skin, body, and general appearance is often the first to suffer if there is a nutrient imbalance. Hum’s mission is to make you look and feel great with products that compliment your beauty routine from the inside out and provide long-term care, repair, and protection—all in one step.

This set contains 30 packettes (a 30-day supply) that are suitable for vegans and vegetarians.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Size 12 x 1.3 oz/ 36 g sachets (2 of each) · ITEM 2008670
exclusive· limited edition· buzzworthy· online only
$35.00

What it is:
A Complete Moon Dust® Collection—six adaptogenic blends of superherbs and supermushrooms that help build your body's resilience to stress, reducing its harmful effect.

If you want to know more…
Beauty Dust® helps support natural collagen for radiant skin.*

Brain Dust® helps sharpen focus and supports memory.*

Sex Dust® helps support creative energy and boost libido.*

Power Dust® helps boost energy and reduce fatigue.*

Spirit Dust® calms the mind and enhances mood.*

Dream Dust® promotes deep and restful sleep.*

This set contains:
- 2 x 1.3 oz/ 36 g sachets of Beauty Dust, Brain Dust, Sex Dust, Power Dust, Spirit Dust, Dream Dust

What else you need to know:
Adaptogens are plants, mushrooms, and minerals that have traditionally been used to help the body manage stress, whether the source is mental, physical, or emotional. Adaptogens work to restore balance in the adrenal, endocrine, nervous, and immune systems, reducing the impacts of stress (aging, exhaustion, anxiety) on body, beauty, and consciousness from the inside out.

Moon Dust does not fully dissolve. Use a blender, aerolatte, or shaker to thoroughly incorporate, then let the Dust settle.

These products are organic, cruelty-free, gluten free.