Peptides for Skin Barrier Support

  • Overview
  • Retinol: The Wrinkle Fighter
  • Hyaluronic Acid: The Hydration Hero
  • Niacinamide: The Discoloration Eraser
  • Peptides: The Barrier Protector
  • BHA/PHA: The Epic Exfoliator
  • Squalane: The Mega Moisturizer
  • Vitamin C: The Dullness Ditcher
  • Lactic Acid: The Smoothing Wonder
  • Collagen: The Firming Fave

Best Peptide Picks

Clean at Sephora
Youth To The PeopleTriple Peptide Hydrating + Firming Oasis Serum with Hyaluronic Acid
$57.00
539
allure 2025 Best of Beauty Award Winner
SkinfixTriple Lipid-Peptide Cream Refillable Barrier Moisturizer with Ceramides
$54.00
704
Clean at Sephora
OLEHENRIKSENStrength Peptide Barrier Boost Moisturizer with Hyaluronic Acid and Niacinamide
$52.00
1.2K
Clean at Sephora
The INKEY ListPeptide Moisturizer
$12.60 $18.00
946
Peter Thomas RothInstant FIRMx® Eye Temporary Eye Tightener
$38.00
912
Clean at Sephora
FarmacyFilling Good Hyaluronic Acid Plumping Serum
$52.00
955
Clean at Sephora
Drunk ElephantProtini™ Polypeptide Firming Refillable Moisturizer
$72.00
7.7K
Clean at Sephora
The INKEY ListCollagen Booster Firming Peptide Serum
$17.00
626
Clean at Sephora
Tata HarperWater-Lock Refillable Moisturizer with Skin-Smoothing Peptides & Hyaluronic Acid
$72.00
581

FAQs

What are peptides? They are chains of amino acids that support a variety of your skin's natural building blocks, including collagen and elastin.

What do they do for skin? Peptides can perform various functions for the skin, depending on the peptide. For example, some support smoothing the look of wrinkles, others can help with visible firmness, and others boost hydration.

How do peptides work? Our skin naturally contains peptides. They help complement our skin's natural processes.

How do I use them? Peptides can be found in all variety of skincare products—moisturizers, eye creams, masks, etc. Use as directed.

What can I pair them with? They can be part of any skincare routine.

Anything I shouldn’t pair them with? It's not recommended to use peptides and acids during the same routine. For example, if your nighttime routine includes AHAs, keep peptides in your morning routine. This is because acids break down proteins, and peptides are precursors to protein, so acids can make peptides less effective.

Related Content:

CBD Skincare, Lactic Acid for Skin: The Complete Beginner's Guide, Niacinamide for Skin: The Complete Beginner's Guide, Vitamin C for Skin: The Complete Beginner's Guide, Acne-Prone Skincare Routine, Hyaluronic Acid for Skin: The Complete Beginner's Guide, Collagen for Skin: The Complete Beginner's Guide, BHA/PHA Skincare: The Complete Beginner's Guide, Squalane for Skin: The Complete Beginner's Guide