Sephora customers often prefer the following products when searching for Top Acne Spot Treatments.

Browse the top-ranked list of Top Acne Spot Treatments below along with associated reviews and opinions.

Size 0.5 oz/ 15 mL · ITEM 1933100
exclusive· limited edition· buzzworthy· online only
$23.00

It works so well...I love this stuff...2) It is completely useless on anything more than a whitehead unless you want that unattractive layer of dried out skin on top of your blemish....I am a fan of Murad products, and I wanted to really like this, but to be honest it doesn't work any better than a spot 5 dollar spot treatment from a grocery store
What it is: A maximum-strength, two-percent-salicylic-acid gel that soothes the skin, targets acne, and visibly reduces blemish size and redness in as little as four hours.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes and Oiliness

Formulation: Gel

Highlighted Ingredients:
- Salicylic Acid 2%: Penetrates pores to exfoliate and visibly smooth the skin.
- Oat Extract: Soothes the skin and reduces the look of redness.
- Witch Hazel: Absorbs excess oil and visibly tightens pores.

Ingredient Callouts: Free of parabens, formaldehydes, phthalates, mineral oil, oxybenzone, and sulfates SLS & SLES. It is also vegan, gluten-free, and cruelty-free.

What Else You Need to Know: Clear the appearance of blemishes fast. This soothing gel unclogs pores, smooths the skin, and visibly reduces redness. Use it to target emerging and existing blemishes and "maskne" breakouts on the spot.

This product is an Allure Best of Beauty award winner.

Clinical Results: In a clinical test, after 8 weeks of use:
- 100% agreed scar texture looks smoother/more even
- 91% agreed skin roughness on scar looks significantly improved
- 86% agreed scars look less discolored
Size 0.5 oz/ 15 mL · ITEM 2416758
exclusive· limited edition· buzzworthy· online only
$25.00

I like it so far...Overall I like it...If I use this product twice, during the AM time I apply it on top of my moisturizer...I had gotten this as a free sample from Pinchme, and I used it recently due to bad break outs on my skin from not only everyday sweat but from wearing a mask while at work all day, this product is great because it is a spot treatment so you don't have to apply it everywhere if you don't want to, it had a mild tingling feeling on the face, but nothing dramatic, I definitely see a difference in my skin in just a week
What it is: A concentrated formula that targets visible hormonal flare-ups and redness while reducing the appearance of future blemishes.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Redness, Acne and Blemishes, and Oiliness

Formulation: Gel

Highlighted Ingredients:
- Benzoyl Peroxide 5%: An ultra-micronized, non-irritating ingredient that visibly reduces acne.
- REG-ulate360 Complex™: A blend of medical-grade actives that restores a healthy-looking appearance to hormonally imbalanced skin.
- Medical-Grade Aloe Vera: Delivers antioxidants plus vitamins A and C to soothe hormonally imbalanced skin.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone, coal tar, hydroquinone, triclosan, and triclocarban, and contains less than one percent of synthetic fragrances. This product is also cruelty-free and gluten-free.

What Else You Need to Know: This clinical-grade formula targets the look of blemishes, stubborn hormonal acne, and blackheads while addressing excess oil with medical-grade aloe vera and bakuchiol. REG-ulate360 Complex™—a blend with resveratrol, vitamin E, green tea, bakuchiol, and genistein (a plant-derived phytoestrogen)—visibly improves hormonally imbalanced skin while an antioxidant blend nourishes and soothes.
Size 0.5 oz/ 15 mL · ITEM 1697648
exclusive· limited edition· buzzworthy· online only
$19.00

So far I love it...The best there is...My skin is pretty tolerant of "harsher" (I used to go to a clinic to get acid peels, so my skin has been through a lot) - I find this product works well for me, but it REALLY dries your skin out...4 stars because my small acne spots react well to this, however it doesnt come close to touching my cystic acne
What it is:
An advanced acne spot treatment designed to deliver significantly clearer skin, aggressively target active breakouts, and promote healthy healing.

What it is formulated to do:
Say goodbye to blemishes. This rejuvenating Acne Spot Treatment helps rapidly clear and soothe the discomfort of bothersome blemishes for clearer, brighter skin. The antimicrobial formula immediately begins to eliminate acne-causing bacteria, while salicylic acid penetrates pores to clear most unwanted acne blemishes. It is formulated with less potential for irritation, and features a barrier rejuvenation complex that helps soothe the redness of blemishes and quickly reduce the appearance of discoloration.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates
Size 0.68 oz/ 20 mL · ITEM 1989318
exclusive· limited edition· buzzworthy· online only
$30.00

This stuff is ok...Would buy it again...When I applied the spot treatment the night before on to a problem area it would immediately reduce the swelling and the redness and with two nights the pimple would be gone...It's so nice not having to get a q tip and dip it in and try and get an equal amount so it don't end up with a bunch of dried product I can't use at the end of the bottle that's just wasted
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination

What it is:
A spot treatment that targets problem areas on contact to help clear blemishes.

Solutions for:
- Oiliness
- Acne and blemishes

If you want to know more…
Breakout Control Targeted Acne Spot Treatment effectively targets acne and blemishes at the source. Salicylic acid refines skin texture and possesses anti-bacterial properties to suppress acne-causing bacteria, oil-absorbing ginger root extract delivers gingerols to soothe skin, and frankincense helps reduce sebum production.

What it is formulated WITHOUT:
- Parabens
- Sulfates
- Phthalates

What else you need to know:
This product was inspired by the original Blue Astringent Herbal Lotion formulated in 1964, and is tested under dermatologist supervision. As part of your acne-free skincare routine, start using the Blue Herbal Gel Cleanser, followed by the Blue Astringent Herbal Lotion and Blue Herbal Moisturizer.

Kiehl’s is inspired by its rich heritage as an old-world apothecary, applying over 165 years’ worth of cosmetic, pharmaceutical, herbal, and medicinal knowledge into the formulations. They utilize the finest natural ingredients and incorporate advanced scientific technologies to ensure the highest quality and most efficacious formulas without compromise. They are protective of the environment as they maximize the use of renewable, sustainable, and biodegradable ingredients. Kiehl’s proudly stands behind the quality, efficacy, and safety of each of their products.
Size 0.5 oz/ 15 mL · ITEM 2289239
exclusive· limited edition· buzzworthy· online only
$55.00

However, I love it...My complexion is 95% clearer and the blemishes have been under control...But girl TRUST when I say I've had crazy acne for years, and legit this is the only spot treatment that has given me consistent and reliable results...I use her Clarifying Serum mixed with the Hyaluronic Serum and saw that people really liked the spot treatment so I ordered one
What it is: An untinted, transparent, anti-blemish gel that addresses imperfections and impurities at the source.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Dark Spots, Acne and Blemishes, and Redness

Formulation: Gel

Highlighted Ingredients:
- Complex of Maclura Bioflavonoids, Tea Tree Oil, and Zinc Oxides: Help to reduce the appearance of spots, blemishes, and redness.

Ingredient Callouts: This product is cruelty-free, and gluten-free.

What Else You Need to Know: The clear formula quickly reduces the appearance of redness, spots, and skin imperfections. An effective combination of maclura bioflavonoids, tea tree oil and zinc oxide help to reduce the appearance of unpleasant blemishes from the very first application.

As an aesthetic doctor with a background in anti-inflammatory medicine, Dr. Sturm is committed to treating the skin with scientifically-proven ingredients and non-aggressive natural extracts. The three pillars of Dr. Barbara Sturm Molecular Cosmetics—hydration, boosting the skin’s natural barrier function, and reducing the visible signs of irritation—help to promote healthy skin that glows from within over time.

Clean at Sephora
Clean at Sephora is formulated without a list of over 50 ingredients, including sulfates (SLS and SLES), parabens, phthalates, and more. For the full list, check out the Ingredients tab.
Size 1 oz/ 30 mL · ITEM 1592831
exclusive· limited edition· buzzworthy· online only
$27.50

Gets the job done...Magic in a Bottle...However, as everyone with acne issues would agree, it is not a complete acne treatment, you'd always need benzoyl peroxide for a more effective acne treatment, Salicylic acid is great but can't treat all types of acne...I have pcos and my acne is horrible, I have tried antibiotics topical treatment prescribed from my doctor nothing helped my cystic acne, decided to try my sample and noticed a huge difference in the morning, this is amazing I am actually hopefully I can get rid of my acne and have a clear face again like I use to
What it is: A topical formula for breakouts with results as good as a leading prescription.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Lightweight Gel

Highlighted Ingredients:
- Salicylic Acid: Clears dead skin cells that can contribute to clogged pores.
- Witch Hazel: Minimizes shine on the skin‘s surface and tightens the appearance of pores.
- Laminaria Saccharina Extract: Helps decrease oil buildup that can lead to breakouts.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates. This product is also gluten-free.

What Else You Need to Know: This formula with salicylic acid helps clear the look of blemishes. It also helps prevent new ones from making an unwelcome appearance. If you have acne-prone skin with persistent blemishes, use this fast-drying formula all over your face or as a spot treatment.
Size 0.5 oz/ 15 mL · ITEM 1592856
exclusive· limited edition· buzzworthy· online only
$18.50

But it does work...No scar was left...On one hand, yes it works and my acne goes down (not overnight though, it takes a few days of consistently using it twice a day), but sometimes it does irritate my skin & it feels like the acne spot is burning...A thin layer and a good oil-free moisturizer are the keys to getting rid of those zits and making sure you don't dry out your skin
What it is: A topical formula for breakouts with results as good as a leading prescription.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Lightweight Gel

Highlighted Ingredients:
- Salicylic Acid: Clears dead skin cells that can contribute to clogged pores.
- Witch Hazel: Minimizes shine on the skin‘s surface and tightens the appearance of pores.
- Laminaria Saccharina Extract: Helps decrease oil buildup that can lead to breakouts.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates. This product is also gluten-free.

What Else You Need to Know: This formula with salicylic acid helps clear the look of blemishes. It also helps prevent new ones from making an unwelcome appearance. If you have acne-prone skin with persistent blemishes, use this fast-drying formula all over your face or as a spot treatment.
Size 1 oz · ITEM 1167147
exclusive· limited edition· buzzworthy· online only
$26.00

It helps so much...It's a life saver...A sale associate named Olinda at Emeryville Ca, recommended this amazing Kate Somerville EradiKate Acne Treatment for my emergency spot treatment and she gave me sample to try it 1st because my skin is an acne prone skin and using this product is A M A Z I N G. just spot treatment and it will demolish that stubborn zit/blemish that we all hate with a passion so thanks Olinda for your recommendations...i'm not too sure about future breakouts as I still breakout occasionally and it's not a product you can smear all over your face but it's great at making a pimple or zit either disappear without even coming to a head (which is rare for me) or it'll make it come to a head faster so that it'll pop on its own then heal faster, than if I didn't put this product on it at all
What it is: An effective blemish-fighting acne spot treatment that minimizes pimples, zaps zits, and helps prevent future breakouts.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Blemishes, Pores, Oiliness

Formulation: Mask

Highlighted Ingredients:
- Sulfur (10.0%): Works quickly to exfoliate dead surface skin cells, unclog pores, and help reduce the appearance of blemishes.
- BHAs: Deliver anti-redness benefits to reduce the look of pores while unclogging them.
- Zinc Oxide: A natural mineral that provides oil control by absorbing excess sebum.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone, coal tar, hydroquinone, triclosan, and triclocarban, and contains less than one percent of synthetic fragrances. This product is also cruelty-free.

What Else You Need to Know: Kate's bestselling EradiKate™ Acne Treatment is formulated with the highest level of sulfur allowed to fight blemishes, reduce acne, and prevent new breakouts. BHAs help visibly reduce pore size, while natural mineral zinc oxide controls oil by absorbing excess sebum.

Clinical Results: In an independent clinical study after just 1 hour:
- 94% showed visible improvement of breakouts

After just 2 days:
- 97% showed visible improvement of redness and inflammation
- 96% reported minimized breakouts and smoother skin
ITEM 1962141
exclusive· limited edition· buzzworthy· online only
$19.00

Instead of taking a week or more for a painful, swollen cystic acne pimple to come to a head and move along, these dots make it come to a head in one night's use and then after two night's use, it is completely flat and no longer hurts...after going on BC my breakouts haven't been as bad and are pretty limited to the week around my period, but it was a pain having to wait for those spots to go away and heal, so it would feel like i'd be acne free (not including scars/pigmentation) for only a week until my hormonal breakouts would start to flare up again
What it is: A pack of the original acne treatment dots that combine healing hydrocolloid polymer technology with salicylic acid to minimize breakouts overnight.

Skin Type:
Normal, Dry, Combination, and Oily

Skincare Concerns: Redness and Acne and Blemishes

Highlighted Ingredients:
- Salicylic Acid: Penetrates pores to target acne blemishes and blackheads.
- Aloe Vera Leaf Extract: Gently soothes while minimizing the appearance of redness.
- Vitamin A: Helps promote clear-looking skin.

Ingredient Callouts: Free of parabens, formaldehydes, formaldehyde-releasing agents, phthalates, retinyl palmitate, hydroquinone, sulfates SLS & SLES, triclocarban, triclosan, and contains less than one percent synthetic fragrance. It is also vegan, gluten-free, and cruelty-free.

What Else You Need to Know: The only OTC acne treatment dot, these are the first of their kind to bring hydrocolloid polymer technology and anti-acne active ingredient salicylic acid together for a focused treatment that minimizes the appearance of blemishes and breakouts in as little as eight hours (or overnight).

Clinical Results: In a consumer study:
- 91% of participants said that after using the product, their blemish was less red, less uncomfortable, and significantly less annoying in 6 hours
- 91% of participants said that the product healed the acne that it was applied to
- 95% of participants said the product helped soothe their skin where it was applied
Size 0.5 oz/ 15 ml · ITEM 1989276
exclusive· limited edition· buzzworthy· online only
$20.00

I LOVE THIS STUFF...Works Wonders For Me...It took me a while to find a spot treatment that works and now that I have, I'm very happy...This product lets me throw on a little dot on an incoming spot at night and not worry about it the next day
Which skin type is it good for?
✔ Normal
✔ Oily
✔ Combination

What it is:
A spot treatment that targets problem areas on contact to help clear blemishes.

Solutions for:
- Oiliness
- Acne and blemishes

If you want to know more…
Formulated for acne prone or oily skin, this treatment contains two percent salicylic acid to penetrates into pores and reduce acne breakouts. salicylic acid has antibacterial properties to suppress acne-causing bacteria and diminish breakouts. Frankincense helps to reduce oiliness, and ginger root extract soothes and absorbs excess oil for visibly calmer skin.

What else you need to know:
This product is tested under dermatologist supervision. It was inspired by the original Blue Astringent Herbal Lotion, which was formulated in 1964.

Kiehl’s is inspired by its rich heritage as an old-world apothecary, applying over 165 years’ worth of cosmetic, pharmaceutical, herbal, and medicinal knowledge into the formulations. They utilize the finest natural ingredients and incorporate advanced scientific technologies to ensure the highest quality and most efficacious formulas without compromise. They are protective of the environment as they maximize the use of renewable, sustainable, and biodegradable ingredients. Kiehl’s proudly stands behind the quality, efficacy, and safety of each of their products.
Size 0.5 oz/ 15 mL · ITEM 2270072
COLOR: 01 [ 2 more colors ]
exclusive· limited edition· buzzworthy· online only
$55.00

Pricey, but worth it...This stuff is magical...I don't think it provides enough coverage on its own in all scenarios (like darker spots), but I like to use it as a base on those problem areas and if I need more coverage I use Make Up For Ever - Full Cover on top of it...I recently took advantage of the sephora sale and splurged on the entire Barbara Sturm Clarifying line and I love this spot treatment
What it is: A tinted spot treatment designed to cover up and address blemishes, breakouts, and redness.

Skin Type: Combination and Oily

Skincare Concerns: Redness, Acne, and Blemishes

Highlighted Ingredients:
- Complex of Maclura Bioflavonoids, Tea Tree Oil, and Zinc Oxide: Helps combat unwanted impurities.
- Vitamin B3: Supports the body’s natural skin renewal.

Ingredient Callouts: This product is vegan, cruelty-free, and gluten-free.

What Else You Need to Know: Formulated with an active complex of maclura bioflavinoids, tea tree oil, and zinc oxides, this spot treatment helps to diminish unwanted impurities.

As an aesthetic doctor with a background in anti-inflammatory medicine, Dr. Sturm is committed to treating the skin with scientifically-proven ingredients and non-aggressive natural extracts. The three pillars of Dr. Barbara Sturm Molecular Cosmetics—hydration, boosting the skin’s natural barrier function, and reducing the visible signs of irritation—help to promote healthy skin that glows from within over time.

Clean at Sephora
Clean at Sephora is formulated without a list of over 50 ingredients, including sulfates (SLS and SLES), parabens, phthalates, and more. For the full list, check out the Ingredients tab.