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72 Hour Hydration Face Moisturizers

Sephora customers often prefer the following products when searching for 72 Hour Hydration Face Moisturizers.

Discover the secret to long-lasting, supple skin with 72 Hour Hydration Face Moisturizers. Perfect for all skin types, these ultra-hydrating formulas are designed to keep your complexion feeling fresh and moisturized day after day. Whether you’re looking to maintain a dewy glow or combat dryness, explore a range of innovative options that deliver continuous hydration and help support a healthy-looking radiance. Find your new skincare essential and experience the difference that lasting moisture can make.

Peter Thomas RothWater Drench® Hyaluronic Cloud Cream Hydrating Refillable Moisturizer

ITEM: 2789972

Size: 1.7 oz / 50 ml

2.1K Reviews

$70.00

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I wouldn't say it "lasts 72 hours" but it's an incredible formulation....Not sure about the 72 hours claim... but it’s light, and perfect for daytime.

What it is: A fluffy-light 30% Hyaluronic Acid Complex cream with Pentavitin®, a breakthrough ingredient that provides hydration for up to 72 hours.*


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Fine Lines and Wrinkles, Dryness, and Dullness


Formulation: Lightweight Cream


Highlighted Ingredients:

- 30% Hyaluronic Acid Complex: Drenches skin with moisture so it appears supple and smooth.

- Pentavitin®: Provides hydration for up to 72 hours—even after cleansing.*

- Ceramides: Moisturize and help leave skin feeling silky soft and smooth.

$87.00

What it is: A rich, oil-free moisturizer that provides up to 72 hours of intense hydration and powerful peptides that visibly plump and firm without causing congestion.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Dryness, and Loss of Firmness and Elasticity

Formulation: Rich Cream

Highlighted Ingredients:
- Peptides: Supports healthy collagen and elasticity while visibly firming and plumping.
- Hydrosella: Provides up to 72 hours of hydration.
- Squalane: Replenishes skin, locks in moisture, and protects skin barrier.

Ingredient Callouts: Free of parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone, c

$82.00

Overall it’s a great moisturizer and I highly recommend it to anyone who likes the 72 hour hydration but needs more moisture than that can provide....The best moisturizer if you have dry or dehydrated skin. It’s the 72 hour one!!!...Amazing moisturizer for dewy and moisturized skin

What it is: A rich cream-gel delivers 72-hour hydration for velvety-smooth skin. A cream formulated with cica, it helps soothe and comfort dry or dehydrated skin.


Skin Type: Dry and Combination


Skincare Concerns: Dryness and Dullness 


Formulation: Rich Cream-Gel


Highlighted Ingredients:
- Hyaluronic Acid: Holds 1,000 times its weight in water, creating a "moisture reservoir" for ideal hydration.

- Activated Aloe Water: Delivers intense hydration.

- Cica: Soothes dry, delicate skin.


Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates.

$26.00

Hydration YES PLZ...Love this moisturizer makes my face feel so hydrated I use it in the morning or night!...Hydration, Hydration, Hydration!! Love this facial moisturizer!

What it is:  Our best-selling hyaluronic acid moisturizer delivers 72-hour deep hydration* with strengthening damask rose extract for dewy, plump skin.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dryness, Dullness, and Uneven Texture


Formulation: Cream


Highlighted Ingredients:
- Damask Rose Extract: Retains moisture and supports the skin’s barrier.

- Hyaluronic Acid Duo (1,500 and 50 kDA): Delivers hydration.

- Time-Release Technology: Helps deliver continuous hydration on the skin’s surface.

$19.00

I love how smooth my skin feels and it really does last the 72 hours. I have been using a few of the other products in the line and I am obsessed with the packaging! ...An affordable and reliable moisturizer....This moisturizer helped my skin immensely with hydration.

What it is: An oil-free gel cream that hydrates your skin for up to 72 hours, provides blue light protection, and is made specifically for acne-prone skin.
Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Dryness, Dullness, and Acne and Blemishes

Formulation: Cream

Highlighted Ingredients:
- Pentavitin: Clinically proven to provide up to 72 hours of hydration.
- Ceramides: Improve and support a strong skin barrier.
- Amino Acids: Provide antioxidant protection and support skin's resilience.

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

What Else You Need to Know: This gel cream is a dream on all skin, b

$27.00

A great facial moisturizer!...The SKINFIX Barrier Balancing Water Cream Moisturizer is an amazing moisturizer! It goes on so silky and smooth, absorbs really quickly into my face and I love the way it feels while applying the moisturizer. ...Lightweight, hydrating moisturizer...This is a beautiful, lightweight moisturizer that boosts hydration without being heavy or greasy.

What it is: A weightless moisturizer that delivers a burst of refreshing hydration that lasts three straight days, balanced with an acne-safe, non-pore-clogging formula.

Skin Type: Combination and Oily

Skincare Concerns: Pores, Uneven Texture, and Oiliness

Formulation: Gel

Highlighted Ingredients:
- 2.35% Balancing Complex: Absorbs oil and reduces visible redness with zinc PCA, niacinamide, and green tea.
- 1% Heptapeptide Solution: Balances and encourages healthy-looking skin with prebiotic peptides.
- 2% Humectant Blend: Delivers long-lasting hydration with hyaluronic acid and saccharide isomerate.

Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

$44.00

What it is: A lightweight, dermatologist-tested water cream that nourishes the moisture barrier and delivers fast, cooling hydration.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Dryness, Redness, and Oiliness

Formulation: Cream

Highlighted Ingredients:
- Patented Barrier-Boosting Ceramides Blend: High-density ceramides fill moisture gaps in sensitive skin for hydration.
- Capsule Technology: Keeps ceramides in the skin barrier longer for hydration.
- Compressed Hyaluronic Acid: Retains moisture and absorbs into skin effectively.

Ingredient Callouts: Free of parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone

$96.00

I've put it to the test during long flights, brutal winters, and even sweaty summer days, and it always comes through with flying colors. The 72-hour hydration claim isn't just a marketing ploy—I've genuinely felt the difference in my skin's softness and suppleness. ...Great Moisturizer!...It has a lightweight texture that is truly unique and provides 72-hour hydration, leaving the skin visibly healthier and softer.

What it is: A bestselling face cream formulated with squalane, glacial glycoprotein, and pro-ceramides to support your skin’s barrier for up to 72-hour hydration.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dryness and Dullness


Highlighted Ingredients:
- Squalane: Replenishes skin’s barrier keeping it feeling soft, supple, and moisturized.

- Glacial Glycoprotein: Intensely hydrates and maintains skin’s moisture balance.

- Pro-Ceramides: Reinforce skin’s barrier strength and resist external disruptors.


Ingredient Callouts: Free of parabens.

$32.00

I wanted it to actual leave me hydrated for the 72 hours. I have dry skin and it definitely wouldn't provide that much moisture. ...I have dehydrated skin and past moisturizers would still show face flake/cake especially after foundation.

What it is: A fluffy-light 30% Hyaluronic Acid Complex cream with Pentavitin®, a breakthrough ingredient that helps provide hydration for up to 72 hours.*


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Fine Lines and Wrinkles, Dryness, and Dullness


Formulation: Cream


$103.00

Fresh’s hyaluronic acid moisturizer features a new clean formula with 72-hour hydration and a lightweight texture for plump, dewy skin. ...PERFECT MOISTURIZER...I really like this rose hyaluronic acid moisturizer featuring a new clean formula with 72-hour hydration and a lightweight texture for plump, dewy skin.

What it is: Our best-selling hyaluronic acid moisturizer delivers 72-hour deep hydration* with strengthening damask rose extract for dewy, plump skin.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dryness, Dullness, and Uneven Texture


Formulation: Cream


Highlighted Ingredients:
- Damask Rose Extract: Retains moisture and supports the skin’s barrier.

- Hyaluronic Acid Duo (1,500 and 50 kDA): Delivers hydration.

- Time-Release Technology: Helps deliver continuous hydration on the skin’s surface.

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