Best Treatments for Acne

Sephora customers often prefer the following products when searching for Best Treatments for Acne.

Dealing with acne can be frustrating and discouraging, but fear not – there are effective treatments available to help you achieve clear, radiant skin. Whether you're battling occasional breakouts or struggling with persistent acne, finding the right treatment can make all the difference. From over-the-counter remedies to at-home tools, this page is your ultimate guide to discovering the best treatments for acne. We'll explore various options that address different types of acne and provide valuable insights to help you make informed decisions on your journey towards a blemish-free complexion.

Paula's ChoiceClinical PRO Retinaldehyde Dual-Retinoid Treatment for Clear, Luminous Skin

ITEM: 2784890

Size: 1 oz / 30 mL

690 Reviews

$68.00

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love this treatment!...This treatment is great. I have acne prone skin and love using retinol treatments on my face. ...There’s no better brand for acne-prone skin than Paula’s Choice! The clinical pro retinaldeyde dual-retinoid treatment works wonders for hyperpigmentation and texture and I couldn’t recommend it more!

What it is: A high-potency dual retinoid formula delivers derm-level results for clear, luminous skin with minimal chance of irritation—no prescription needed.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Fine Lines and Wrinkles, Uneven Texture, and Acne and Blemishes


Formulation: Cream


Highlighted Ingredients:
- Retinaldehyde: Calcium encapsulated for advanced results with minimized irritation.

- Adapinoid: An oil-soluble retinoid that promotes clear-looking skin.

- Pomegranate Peel Extract: Supports healthy collagen production and soothes.

$65.00

This serum like treatment is so good it blew my minds. I used it for 3 nights and have already seen an improvement on my dark spots and acne marks. ...I have been using this pretty consistently for about 5 weeks now and have noticed a slight change in my overall complexion. ...Its good for evening redness/no for acne scars...Best for acne scars

What it is: Now with a new look and potent Vitamin C, this is a cult-favorite Niacinamide treatment for expert-level brightening results. 


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dark Spots, Dullness, and Uneven Texture


Formulation: Lightweight Cream


Highlighted Ingredients:
- Brightening Complex 15%: Brightens the look of discoloration, dark spots, and post-acne marks.

- THD Ascorbate Vitamin C: Is an ultra-stable form of vitamin C that boosts the visibly brightening effect.


Ingredient Callouts: Free of parabens, formaldehydes, fo

$25.00

Effective solution for acne...This product delivers as promised and is an effective solution for acne issues....direct treatment for acne spots...After using it for a few weeks I really like the formula, recommended #freeproduct

What it is: A targeted cream for acne spots that visibly reduces breakout size in as little as one hour.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Acne and Blemishes, and Oiliness

Highlighted Ingredients:
- 100% Natural Salicylic Acid: Naturally exfoliates and visibly refines skin texture.
- Niacinamide: Minimizes the appearance of pores.
- Tea Tree: Purifies the skin.

Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

What Else You Need to Know: A natural and non-drying purifying cream that targets acne spots fast and reduce breakout size. Use this leave-on cream under makeup to color correct redness with natural green pigments.

$48.00

The BEST blemish treatment I have ever used...The best treatment I have used! The texture is light and silk, not sticky like others.

What it is: A liquid-suspension probiotic specifically designed for blemish-prone skin to significantly reduce the look of breakouts and blemishes and absorb excess sebum production.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Dark Spots, Uneven Texture, and Acne and Blemishes

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

What Else You Need to Know: This liquid-suspension probiotic is specifically designed for blemish-prone skin to significantly reduce the look of breakouts and blemishes and absorb excess sebum production.

Clinical Results: In a test, after 28 days, results showed:
- Inflammatory pustules reduced by 82%

$30.00

My Holy Grail for acne spot treatment....My Holy Grail for acne spot treatment!!! This reduced redness on and around the area of my acne. ...Thank you Skinfix for coming out with a line for acne!! This line was made for me and I absolutely love the ingredients that are in this spot treatment.

What it is: A clinical-strength, rapid-acting acne treatment that visibly reduces blemish size and redness plus helps prevent new acne pimples from forming.

Skin Type:
Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Redness, and Acne/Blemishes

Highlighted Ingredients:
- 2% Salicylic Acid: Decongests pores to help eliminate excess oil and surface debris.
- 10% Azelaic Acid: Helps fade the look of post-acne hyperpigmentation (acne marks/scars) while visibly improving uneven skin tone.
- 2% Niacinamide: Helps minimize the appearance of pores and regulate sebum.

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

$69.00

Suggested Treatment for Acne Prone skin...I have acne prone skin.I have been using it for 8 weeks. ...Awesome for acne...This product was gifted to me from Kate Somerville. This acne fading gel is wonderful! I’ve been using this product for about 4 days now, and I’m already seeing a difference in my acne marks.

What it is: A gel formula to prevent breakouts and visibly diminish post-acne marks in as little as three days while restoring the skin barrier.

Skin Type: Combination and Oily

Skincare Concerns: Pores, Uneven Texture, and Acne/Blemishes

Highlighted Ingredients:
- 2% Salicylic Acid: Diminishes the appearance of breakouts and prevents future acne.
- Prebiotic Complex: Balances and restores skin’s protective microbiome barrier.
- Niacinamide: Visibly evens skin tone from post-acne marks and improves the appearance of pores.

Ingredient Callouts: Free of parabens, phthalates, mineral oil, sulfates SLS & SLES, and contains less than one percent synthetic fragrance. It is also cruelty-free.

$48.00

BEST FOR ACNE...I used this acne treatment for a few days and I noticed BIG results!! ...Effective active treatment...Great retinol for acne prone skin. I love this mighty green retinol cream.

What it is: Experience the first-ever Adapinoid retinoid for acne-prone skin proven to reduce the look of blemishes and pores while restoring skin barrier health. 


Skin Type: Combination and Oily


Skincare Concerns: Pores, Acne/Blemishes, and Oiliness


Formulation: Lightweight Cream


Highlighted Ingredients:

- Adapinoid 0.16%: A brand new ingredient, this powerful retinoid helps reduce blemishes

- Niacinamide 2%: Is a potent antioxidant that absorbs oil and visibly reduces redness

- HydraSoothe: Helps to reduce discomfort, visible redness + boost hydration

$21.00

i love all of what Sephora do product wise especially for acne prone skin. Its such a good price point for good ingredients. ...This product is vegan, great for acne prone skin and suitable for any skin type.

What it is: An acne treatment gel that’s made with 98% ingredients from natural origin and is clinically suitable for acne-prone skin.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Pores, Acne and Blemishes, and Oiliness

Formulation: Lightweight Serum

Highlighted Ingredients:
- Salicylic Acid: Made from gaultheria leaves, it purifies and exfoliates.

Ingredient Callouts: This product is vegan.

What Else You Need to Know: This is an acne treatment gel made in accordance with a strict formulation charter. It includes 2% salicylic acid extracted from gaultheria leaves, known to purify the skin and effectively treat acne, the appearance of pores, blackheads, and sh

$35.00

I have oily, acne-prone skin and iNNBEAUTY PROJECT Acne Serum Medicated Treatment for Acne & Blackheads is gentle on my skin, doesn't feel greasy, and absorbs quickly. ...Solid serum for acne...It’s a nice mild serum for acne treatment. It has a lotion texture that mixes well with other serums.

What it is: A treatment that clears acne and blackheads fast while nourishing the skin's barrier.

Skin Type: Dry, Combination, and Oily

Skincare Concerns: Uneven Texture, Acne and Blemishes, and Oiliness

Highlighted Ingredients:
- 1.5% Salicylic Acid: FDA approved for the treatment of blemishes.
- 6% Skin Barrier Complex: Includes ceramides, lactobacillus ferment, and botanical extracts to support skin’s barrier and balance oil production.
- 4% Tranexamic Acid and Niacinamide: Visibly improves hyperpigmentation.

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

What Else You Need to Know: This is an FDA-approved, non-drying, bl

$35.00

Best spot treatment out there...This is the best spot treatment. Many spot treatments dry up the pimple and surrounding skin and leave an angry pigmented spot. ...Favorite product for acne. Never let myself run out. Yes it smells like sulfur.

What it is: A cream that visibly alleviates pimples and blemishes, speeding up their disappearance from the first application.

Skin Type: Combination and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Cream

Highlighted Ingredients:
- Shale Oil: Supports sebum regulation and fights microbes.
- Tiger Grass: Has soothing and visibly renewing properties.
- Prebiotics and Probiotics: Support the skin's own defense mechanisms.

Ingredient Callouts: Free of parabens, phthalates, mineral oil, triclocarban, triclosan, and contains less than one percent synthetic fragrance. It is also gluten-free.

What Else You Need to Know: The Ultimate Stinky Pimple Treatment harnesses the m

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“Favorite benzoyl peroxide treatment! Love this for keeping my skin clear. Clears up blemishes quickly and hasn’t irritated my skin at all”
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“Dries pimple quicker than other treatments I’ve tried before. It is a bit pricey for the size but it is the same for other acne spot treatments”
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“It will also take a few nights for a cyst to totally go away but you don't get the annoying side affects such as dryness or peeling - which I've gotten with other spot treatments”
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“Paula’s Choice CLINICAL Pro Retinaldehyde Dual-Retinoid Treatment truly did wonders for my skin. If you have uneven skin texture, post acne scars, or acne in general, this product is for you”
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“I loved this retinol treatment! I thought the formula was very nice, and it definitely improved my skin”
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“Unlike some other retinoid treatments, the Equilibrium Resurfacing Retinoid Treatment does not cause irritation or redness, making it suitable for most sensitive skin types.I have noticed a significant improvement in the overall texture and tone of my skin”
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“Ever since then, I’ve been trying many products but they either aren’t strong enough or are too strong and irritate my skin”
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“I’ve tried so many different cleansers throughout the years but I always found that I needed to constantly search for new ones because my skin would clear up for awhile, and go back to how it was before; acne breakouts mainly in my t-zone area and occasional hormonal breakouts along my jawline (sometimes cystic) This cleanser, along with Clinique clarifying lotion, absolutely transformed my skin, shrunk my pores, cleaned up all my breakouts and keeps my skin looking the best it ever has, has even helped with my cystic acne, I cannot recommend two products any more than I can these, a must buy if you have mild acne”
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“Love using this treatment and I’m truly amazed by the results. This retinol treatment helps to reduce dark spots and fine line and wrinkles”

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